Advertisement 1

Sarah Roth: Personalized oncology is the path to rendering cancer a manageable disease

Opinion: B.C. Cancer has made strides with treatment tailored to each person’s unique cancer, which spares healthy tissue while minimizing toxicity

Article content

We are living in one of the most exciting eras of cancer research and care. For the first time, scientists are more hopeful than ever that cancer can become a manageable disease within the next decade. Personalized oncology holds the key to this future, but due to its complexity, it comes at a cost.

Article content
Article content
Article content

On World Cancer Day, beyond the statistics, we are reminded that every cancer patient is a person — a mother, a sister, a husband, or a friend — and their care must reflect that. Together, we can invest in precision medicine and innovative diagnostic tools to ensure targeted treatments are available to everyone facing this disease.

Article content
Advertisement 1
Story continues below
Article content
Article content

For decades, cancer treatment relied on a standard protocol of surgery, chemotherapy and/or radiation, or a combination of all three. While essential, these treatments often lacked precision, rendering them blunt instruments against a disease that has mastered adaptation and survival. Harsh, debilitating side effects and long recoveries were often inevitable.

Article content
Article content
Article content

As our understanding of cancer has evolved, so too has the promise of personalized oncology — treatment tailored to each person’s unique cancer, down to its DNA. This precision spares healthy tissue while targeting disease with extraordinary accuracy, minimizing toxicity and improving patients’ quality of life.

Article content
Article content

B.C. Cancer has made significant strides in this area and we are already witnessing the impact on patient care. Radiation can now be targeted to within millimetres, while genomics and molecular biology allow doctors to understand a patient’s cancer at a cellular level. By analyzing genetic mutations and biomarkers, oncologists can select treatments more likely to target each individual’s cancer.

Article content
Advertisement 2
Story continues below
Article content
Article content

The importance of these advances cannot be overstated. Last year, more than 34,000 British Columbians were newly diagnosed with cancer. Making up these diagnoses are more than 200 distinct cancer types, each with varying subtypes that behave differently in individual patients.

Article content
Article content

B.C. Cancer researchers achieved a world first when they classified breast cancer into 10 distinct subtypes. This groundbreaking discovery has led to a deeper understanding of breast cancer risk. With donor funding, B.C. Cancer’s Hereditary Cancer Program has implemented genetic testing for breast cancer patients under 60, helping to identify BRCA gene mutations, which increase cancer risk by up to 70 per cent.

Article content
Article content

Backed by B.C. Cancer Foundation support, Dr. Sam Aparicio and his team conducted pioneering research on triple negative breast cancer (TNBC), a particularly aggressive subtype often found in younger women. Preliminary findings revealed that whole genome sequencing is up to 100 times more sensitive than alternative approaches, allowing for earlier relapse detection — sometimes up to two years before it occurs. This early detection is critical for timely and targeted interventions, potentially saving lives.

Advertisement 1
Advertisement 2
Advertisement
Article content
Article content

Another example of personalized oncology’s impact is Dante Pasquale, a metastatic prostate cancer patient who benefitted from a B.C. Cancer Foundation-funded circulating tumor DNA (ctDNA) clinical trial. This trial studies the unique properties of cancer using only a blood sample, offering insights that traditional methods could not. Dante’s results revealed a mutation that responds well to immunotherapy — a leading-edge therapy that harnesses the patient’s immune system to attack cancer cells. For many prostate cancer patients, this therapy is ineffective, but thanks to this trial, Dante received life-saving treatment. Today, four years later, he is thriving.

Article content
Article content

With B.C. Cancer Foundation donor support, a Next Generation PET/CT arrives at B.C. Cancer – Vancouver this year. This transformative technology reduces scan times from 40 minutes to just two minutes, increasing capacity to treat more patients and supporting further precision medicine research.

Article content
Advertisement 3
Story continues below
Article content
Article content

B.C. Cancer’s senior executive director of research, Dr. Fran?ois Bénard says, “It’s not something I thought I would see in my career. When I started, it took 90 minutes to scan one patient.”

Article content
Article content

Dr. Bénard and his team are particularly excited about the Next Generation PET/CT’s potential to advance theranostics, which uses one radioactive drug to detect cancer and another to deliver treatment — enabling the optimal dose needed to treat a patient’s cancer while protecting healthy tissue.

Article content
Article content

With four new B.C. Cancer centres on the way, bringing the provincial total to 10, patients in B.C. will benefit from donor-driven innovation in treatment, technology and research closer to home.

Article content
Article content

Without philanthropy, all this progress in understanding, treating and preventing cancer would be unimaginable; researchers would face severe limitations in resources, hindering their ability to pursue bold, high-risk ideas that revolutionize cancer care, leaving patients with fewer treatment options.

Article content
Article content

To fully conquer the greatest health challenge of our time, we must come together and invest even further in the future of personalized oncology. We owe it to the one in two people we love, who will face cancer one day, to ensure they receive the individualized, cutting-edge cancer care they deserve.

Article content
Article content

Sarah Roth is president and CEO of the B.C. Cancer Foundation.

Article content

Article content
Advertisement 2
Comments
You must be logged in to join the discussion or read more comments.
Join the Conversation

Postmedia is committed to maintaining a lively but civil forum for discussion. Please keep comments relevant and respectful. Comments may take up to an hour to appear on the site. You will receive an email if there is a reply to your comment, an update to a thread you follow or if a user you follow comments. Visit our Community Guidelines for more information.

universo-virtual.com
buytrendz.net
thisforall.net
benchpressgains.com
qthzb.com
mindhunter9.com
dwjqp1.com
secure-signup.net
ahaayy.com
soxtry.com
tressesindia.com
puresybian.com
krpano-chs.com
cre8workshop.com
hdkino.org
peixun021.com
qz786.com
utahperformingartscenter.org
maw-pr.com
zaaksen.com
ypxsptbfd7.com
worldqrmconference.com
shangyuwh.com
eejssdfsdfdfjsd.com
playminecraftfreeonline.com
trekvietnamtour.com
your-business-articles.com
essaywritingservice10.com
hindusamaaj.com
joggingvideo.com
wandercoups.com
onlinenewsofindia.com
worldgraphic-team.com
bnsrz.com
wormblaster.net
tongchengchuyange0004.com
internetknowing.com
breachurch.com
peachesnginburlesque.com
dataarchitectoo.com
clientfunnelformula.com
30pps.com
cherylroll.com
ks2252.com
webmanicura.com
osostore.com
softsmob.com
sofietsshotel.com
facetorch.com
nylawyerreview.com
apapromotions.com
shareparelli.com
goeaglepointe.com
thegreenmanpubphuket.com
karotorossian.com
publicsensor.com
taiwandefence.com
epcsur.com
odskc.com
inzziln.info
leaiiln.info
cq-oa.com
dqtianshun.com
southstills.com
tvtv98.com
thewellington-hotel.com
bccaipiao.com
colectoresindustrialesgs.com
shenanddcg.com
capriartfilmfestival.com
replicabreitlingsale.com
thaiamarinnewtoncorner.com
gkmcww.com
mbnkbj.com
andrewbrennandesign.com
cod54.com
luobinzhang.com
bartoysdirect.com
taquerialoscompadresdc.com
aaoodln.info
amcckln.info
drvrnln.info
dwabmln.info
fcsjoln.info
hlonxln.info
kcmeiln.info
kplrrln.info
fatcatoons.com
91guoys.com
signupforfreehosting.com
faithfirst.net
zjyc28.com
tongchengjinyeyouyue0004.com
nhuan6.com
oldgardensflowers.com
lightupthefloor.com
bahamamamas-stjohns.com
ly2818.com
905onthebay.com
fonemenu.com
notanothermovie.com
ukrainehighclassescort.com
meincmagazine.com
av-5858.com
yallerdawg.com
donkeythemovie.com
corporatehospitalitygroup.com
boboyy88.com
miteinander-lernen.com
dannayconsulting.com
officialtomsshoesoutletstore.com
forsale-amoxil-amoxicillin.net
generictadalafil-canada.net
guitarlessonseastlondon.com
lesliesrestaurants.com
mattyno9.com
nri-homeloans.com
rtgvisas-qatar.com
salbutamolventolinonline.net
sportsinjuries.info
topsedu.xyz
xmxm7.com
x332.xyz
sportstrainingblog.com
autopartspares.com
readguy.net
soniasegreto.com
bobbygdavis.com
wedsna.com
rgkntk.com
bkkmarketplace.com
zxqcwx.com
breakupprogram.com
boxcardc.com
unblockyoutubeindonesia.com
fabulousbookmark.com
beat-the.com
guatemala-sailfishing-vacations-charters.com
magie-marketing.com
kingstonliteracy.com
guitaraffinity.com
eurelookinggoodapparel.com
howtolosecheekfat.net
marioncma.org
oliviadavismusic.com
shantelcampbellrealestate.com
shopleborn13.com
topindiafree.com
v-visitors.net
qazwsxedcokmijn.com
parabis.net
terriesandelin.com
luxuryhomme.com
studyexpanse.com
ronoom.com
djjky.com
053hh.com
originbluei.com
baucishotel.com
33kkn.com
intrinsiqresearch.com
mariaescort-kiev.com
mymaguk.com
sponsored4u.com
crimsonclass.com
bataillenavale.com
searchtile.com
ze-stribrnych-struh.com
zenithalhype.com
modalpkv.com
bouisset-lafforgue.com
useupload.com
37r.net
autoankauf-muenster.com
bantinbongda.net
bilgius.com
brabustermagazine.com
indigrow.org
miicrosofts.net
mysmiletravel.com
selinasims.com
spellcubesapp.com
usa-faction.com
snn01.com
hope-kelley.com
bancodeprofissionais.com
zjccp99.com
liturgycreator.com
weedsmj.com
majorelenco.com
colcollect.com
androidnews-jp.com
hypoallergenicdogsnames.com
dailyupdatez.com
foodphotographyreviews.com
cricutcom-setup.com
chprowebdesign.com
katyrealty-kanepa.com
tasramar.com
bilgipinari.org
four-am.com
indiarepublicday.com
inquick-enbooks.com
iracmpi.com
kakaschoenen.com
lsm99flash.com
nana1255.com
ngen-niagara.com
technwzs.com
virtualonlinecasino1345.com
wallpapertop.net
nova-click.com
abeautifulcrazylife.com
diggmobile.com
denochemexicana.com
eventhalfkg.com
medcon-taiwan.com
life-himawari.com
myriamshomes.com
nightmarevue.com
allstarsru.com
bestofthebuckeyestate.com
bestofthefirststate.com
bestwireless7.com
declarationintermittent.com
findhereall.com
jingyou888.com
lsm99deal.com
lsm99galaxy.com
moozatech.com
nuagh.com
patliyo.com
philomenamagikz.net
rckouba.net
saturnunipessoallda.com
tallahasseefrolics.com
thematurehardcore.net
totalenvironment-inthatquietearth.com
velislavakaymakanova.com
vermontenergetic.com
sizam-design.com
kakakpintar.com
begorgeouslady.com
1800birks4u.com
2wheelstogo.com
6strip4you.com
bigdata-world.net
emailandco.net
gacapal.com
jharpost.com
krishnaastro.com
lsm99credit.com
mascalzonicampani.com
sitemapxml.org
thecityslums.net
topagh.com
flairnetwebdesign.com
bangkaeair.com
beneventocoupon.com
noternet.org
oqtive.com
smilebrightrx.com
decollage-etiquette.com
1millionbestdownloads.com
7658.info
bidbass.com
devlopworldtech.com
digitalmarketingrajkot.com
fluginfo.net
naqlafshk.com
passion-decouverte.com
playsirius.com
spacceleratorintl.com
stikyballs.com
top10way.com
yokidsyogurt.com
zszyhl.com
16firthcrescent.com
abogadolaboralistamd.com
apk2wap.com
aromacremeria.com
banparacard.com
bosmanraws.com
businessproviderblog.com
caltonosa.com
calvaryrevivalchurch.org
chastenedsoulwithabrokenheart.com
cheminotsgardcevennes.com
cooksspot.com
cqxzpt.com
deesywig.com
deltacartoonmaps.com
despixelsetdeshommes.com
duocoracaobrasileiro.com
fareshopbd.com
goodpainspills.com
kobisitecdn.com
makaigoods.com
mgs1454.com
piccadillyresidences.com
radiolaondafresca.com
rubendorf.com
searchengineimprov.com
sellmyhrvahome.com
shugahouseessentials.com
sonihullquad.com
subtractkilos.com
valeriekelmansky.com
vipasdigitalmarketing.com
voolivrerj.com
zeelonggroup.com
1015southrockhill.com
10x10b.com
111-online-casinos.com
191cb.com
3665arpentunitd.com
aitesonics.com
bag-shokunin.com
brightotech.com
communication-digitale-services.com
covoakland.org
dariaprimapack.com
freefortniteaccountss.com
gatebizglobal.com
global1entertainmentnews.com
greatytene.com
hiroshiwakita.com
iktodaypk.com
jahatsakong.com
meadowbrookgolfgroup.com
newsbharati.net
platinumstudiosdesign.com
slotxogamesplay.com
strikestaruk.com
trucosdefortnite.com
ufabetrune.com
weddedtowhitmore.com
12940brycecanyonunitb.com
1311dietrichoaks.com
2monarchtraceunit303.com
601legendhill.com
850elaine.com
adieusolasomade.com
andora-ke.com
bestslotxogames.com
cannagomcallen.com
endlesslyhot.com
iestpjva.com
ouqprint.com
pwmaplefest.com
qtylmr.com
rb88betting.com
buscadogues.com
1007macfm.com
born-wild.com
growthinvests.com
promocode-casino.com
proyectogalgoargentina.com
wbthompson-art.com
whitemountainwheels.com
7thavehvl.com
developmethis.com
funkydogbowties.com
travelodgegrandjunction.com
gao-town.com
globalmarketsuite.com
blogshippo.com
hdbka.com
proboards67.com
outletonline-michaelkors.com
kalkis-research.com
thuthuatit.net
buckcash.com
hollistercanada.com
docterror.com
asadart.com
vmayke.org
erwincomputers.com
dirimart.org
okkii.com
loteriasdecehegin.com
mountanalog.com
healingtaobritain.com
ttxmonitor.com
bamthemes.com
nwordpress.com
11bolabonanza.com
avgo.top